Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC005
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-08-02 07:05
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Carboma a 100mg 4x1 caps Madopar HBS a 125mg 2 uvece tbl Oprimea a 0,52mg 1x1 tbl Rivotril a 2mg 1/2 tbl Elicea a 5mg 1x1 Older patient

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 25 individuals with a value less than 0.6 were subsequently diagnosed with PD. That is, 59.52% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.6 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 41, 'TN': 30, 'TP': 1, 'FP': 0}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 26, 'TN': 22, 'TP': 16, 'FP': 8}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 0, 'TN': 0, 'TP': 42, 'FP': 30}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 5, 'TN': 3, 'TP': 37, 'FP': 27}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 6.268
timePerCircleCoV 0.231192
timePerCircleSlope -0.0594458
meanError 1.6977
tremorFreq 8.59375
tremorRelPower 32.9333
tremorGyroAmpMean 0.040056
tremorGyroAmpSlope -0.0171003
tremorGyroAmpCoV 0.497642
tremorCoordAmpMean 0.129033
tremorCoordAmpSlope -0.0087698
tremorCoordAmpCoV 0.444959
tremorAccAmpMean 0.105997
tremorAccAmpSlope -0.00895635
tremorAccAmpCoV 0.444546
tremorPcRelVar 0.918779
tremorPcX 0.14287
tremorPcY 0.989742

Circle Segment 1

Duration 8.8 s, Accuracy Estimate 1.662 (lower is better)

Circle Segment 2

Duration 8.88 s, Accuracy Estimate 1.685 (lower is better)

Circle Segment 3

Duration 6.56 s, Accuracy Estimate 2.03 (lower is better)

Circle Segment 4

Duration 5.4 s, Accuracy Estimate 1.728 (lower is better)

Circle Segment 5

Duration 5.28 s, Accuracy Estimate 1.783 (lower is better)

Circle Segment 6

Duration 5.52 s, Accuracy Estimate 1.514 (lower is better)

Circle Segment 7

Duration 6.32 s, Accuracy Estimate 1.609 (lower is better)

Circle Segment 8

Duration 5.6 s, Accuracy Estimate 1.511 (lower is better)

Circle Segment 9

Duration 5.6 s, Accuracy Estimate 1.38 (lower is better)

Circle Segment 10

Duration 4.72 s, Accuracy Estimate 2.076 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 10.952
timePerSpiralCoV 0.0988268
timePerSpiralSlope -0.00783585
meanError 2.18009
tremorFreq 8.49609
tremorRelPower 27.5773
tremorGyroAmpMean 0.0452882
tremorGyroAmpSlope -0.00150733
tremorGyroAmpCoV 0.279758
tremorCoordAmpMean 0.145472
tremorCoordAmpSlope -0.00117857
tremorCoordAmpCoV 0.480425
tremorAccAmpMean 0.108775
tremorAccAmpSlope -0.00142352
tremorAccAmpCoV 0.299645
tremorPcRelVar 0.85616
tremorPcX -0.283249
tremorPcY -0.959046

Spiral Segment 1

Duration 13.4 s, Accuracy Estimate 1.799 (lower is better)

Spiral Segment 2

Duration 10.8 s, Accuracy Estimate 2.182 (lower is better)

Spiral Segment 3

Duration 10.84 s, Accuracy Estimate 2.076 (lower is better)

Spiral Segment 4

Duration 9.84 s, Accuracy Estimate 2.217 (lower is better)

Spiral Segment 5

Duration 10.04 s, Accuracy Estimate 2.782 (lower is better)

Spiral Segment 6

Duration 11.08 s, Accuracy Estimate 2.01 (lower is better)

Spiral Segment 7

Duration 10.28 s, Accuracy Estimate 2.464 (lower is better)

Spiral Segment 8

Duration 11.32 s, Accuracy Estimate 1.888 (lower is better)

Spiral Segment 9

Duration 10.0 s, Accuracy Estimate 2.574 (lower is better)

Spiral Segment 10

Duration 11.92 s, Accuracy Estimate 1.807 (lower is better)

Elel

eDurationMean 0.328857
eDurationStd 0.0669293
eDurationStdnorm 0.203521
eDurationMedian 0.32
eDurationQuartdelta 0.0725
eDurationQuartdeltanorm 0.226563
eDurationKurt 4.17938
eDurationTrenddiff 0
eDurationTrendratio 1
eWidthMean 4.7502
eWidthStd 2.08394
eWidthStdnorm 0.438705
eWidthMedian 4.68
eWidthQuartdelta 2.07675
eWidthQuartdeltanorm 0.44375
eWidthKurt 8.6035
eWidthTrenddiff -1.287
eWidthTrendratio 0.744186
eHeightMean 10.6737
eHeightStd 3.1627
eHeightStdnorm 0.296307
eHeightMedian 10.062
eHeightQuartdelta 3.1005
eHeightQuartdeltanorm 0.30814
eHeightKurt 7.00223
eHeightTrenddiff 1.755
eHeightTrendratio 1.19737
eAspectMean 0.459634
eAspectStd 0.183752
eAspectStdnorm 0.399778
eAspectMedian 0.447368
eAspectQuartdelta 0.256554
eAspectQuartdeltanorm 0.573473
eAspectKurt 3.12726
eAspectTrenddiff -0.163945
eAspectTrendratio 0.675262
eSlantMean -0.413944
eSlantStd 0.380406
eSlantStdnorm -0.91898
eSlantMedian -0.486842
eSlantQuartdelta 0.629794
eSlantQuartdeltanorm -1.29363
eSlantKurt 2.73383
eSlantTrenddiff -0.0305479
eRtopMean 0.619766
eRtopStd 0.245259
eRtopStdnorm 0.395729
eRtopMedian 0.615385
eRtopQuartdelta 0.363665
eRtopQuartdeltanorm 0.590955
eRtopKurt 2.46817
eRtopTrenddiff -0.176471
eRbotMean 1.80952
eRbotStd 1.06944
eRbotStdnorm 0.591006
eRbotMedian 1.63158
eRbotQuartdelta 0.81786
eRbotQuartdeltanorm 0.501269
eRbotKurt 8.66184
eRbotTrenddiff 0.518937
eRrightMean 0.770999
eRrightStd 0.175948
eRrightStdnorm 0.228208
eRrightMedian 0.789063
eRrightQuartdelta 0.241137
eRrightQuartdeltanorm 0.305599
eRrightKurt 2.9333
eRrightTrenddiff -0.00592997
eRleftMean 0.600089
eRleftStd 0.193506
eRleftStdnorm 0.322461
eRleftMedian 0.625
eRleftQuartdelta 0.209432
eRleftQuartdeltanorm 0.335092
eRleftKurt 2.94373
eRleftTrenddiff 0.107468
lDurationMean 0.403966
lDurationStd 0.0560991
lDurationStdnorm 0.138871
lDurationMedian 0.4
lDurationQuartdelta 0.05625
lDurationQuartdeltanorm 0.140625
lDurationKurt 4.1337
lDurationTrenddiff -0.0125
lDurationTrendratio 0.969325
lWidthMean 4.61545
lWidthStd 2.17083
lWidthStdnorm 0.470341
lWidthMedian 4.095
lWidthQuartdelta 1.9305
lWidthQuartdeltanorm 0.471429
lWidthKurt 4.34358
lWidthTrenddiff -1.9305
lWidthTrendratio 0.62069
lHeightMean 30.4886
lHeightStd 2.72001
lHeightStdnorm 0.0892139
lHeightMedian 30.303
lHeightQuartdelta 2.83725
lHeightQuartdeltanorm 0.0936293
lHeightKurt 4.84888
lHeightTrenddiff 3.55271e-15
lHeightTrendratio 1
lAspectMean 0.152791
lAspectStd 0.0736592
lAspectStdnorm 0.48209
lAspectMedian 0.141129
lAspectQuartdelta 0.0759133
lAspectQuartdeltanorm 0.5379
lAspectKurt 3.95822
lAspectTrenddiff -0.0712527
lAspectTrendratio 0.598481
lSlantMean -0.22794
lSlantStd 0.0936771
lSlantStdnorm -0.410973
lSlantMedian -0.233577
lSlantQuartdelta 0.115383
lSlantQuartdeltanorm -0.493985
lSlantKurt 2.66341
lSlantTrenddiff -0.0995583
lRtopMean 0.609573
lRtopStd 0.246312
lRtopStdnorm 0.404073
lRtopMedian 0.647059
lRtopQuartdelta 0.226587
lRtopQuartdeltanorm 0.35018
lRtopKurt 3.09048
lRtopTrenddiff -0.194223
lRbotMean 2.625
lRbotStd 1.36502
lRbotStdnorm 0.520007
lRbotMedian 2.25806
lRbotQuartdelta 1.4034
lRbotQuartdeltanorm 0.621506
lRbotKurt 4.23617
lRbotTrenddiff 1.05415
lRrightMean 0.825424
lRrightStd 0.118091
lRrightStdnorm 0.143067
lRrightMedian 0.844697
lRrightQuartdelta 0.17281
lRrightQuartdeltanorm 0.204583
lRrightKurt 3.26917
lRrightTrenddiff -0.112395
lRleftMean 0.625161
lRleftStd 0.144138
lRleftStdnorm 0.230562
lRleftMedian 0.625483
lRleftQuartdelta 0.181907
lRleftQuartdeltanorm 0.290827
lRleftKurt 2.98654
lRleftTrenddiff 0.124824

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

FITTS Short Modified

meanTouchScore 0.966178
sumTouchScores 28.0192
meanMovementTime 0.620893
numTouches 29
undershootPercentage 0
overshootPercentage 6.89655

FITTS Long Modified

meanTouchScore 0.905913
sumTouchScores 19.9301
meanMovementTime 0.798571
numTouches 22
undershootPercentage 0
overshootPercentage 27.2727

ZigZag

numZigzags 6
timePerZigzagMean 10.7
timePerZigzagCoV 0.0588117
timePerZigzagSlope -0.0210414
meanError 2.99098
tremorFreq 6.83594
tremorRelPower 28.5576
tremorGyroAmpMean 0.0813152
tremorGyroAmpSlope -0.00342915
tremorGyroAmpCoV 0.355407
tremorCoordAmpMean 0.122948
tremorCoordAmpSlope -0.00411391
tremorCoordAmpCoV 0.237112
tremorAccAmpMean 0.0920739
tremorAccAmpSlope -0.00184169
tremorAccAmpCoV 0.266356
tremorPcRelVar 0.652912
tremorPcX -0.565603
tremorPcY 0.824678

ZigZag Segment 1

Duration 11.84 s, Accuracy Estimate 2.762 (lower is better)

ZigZag Segment 2

Duration 10.72 s, Accuracy Estimate 2.814 (lower is better)

ZigZag Segment 3

Duration 10.16 s, Accuracy Estimate 2.956 (lower is better)

ZigZag Segment 4

Duration 10.52 s, Accuracy Estimate 2.959 (lower is better)

ZigZag Segment 5

Duration 10.84 s, Accuracy Estimate 3.091 (lower is better)

ZigZag Segment 6

Duration 10.12 s, Accuracy Estimate 3.365 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 8.536
timePerZigzagCoV 0.100864
timePerZigzagSlope -0.0585754
zigzagHeightMean 71.0522
zigzagHeightCoV 0.0829011
zigzagHeightSlope 0.0521194
meanError 0.0384553
tremorFreq 7.8125
tremorRelPower 29.3419
tremorGyroAmpMean 0.108263
tremorGyroAmpSlope 0.00604251
tremorGyroAmpCoV 0.238288
tremorCoordAmpMean 0.200981
tremorCoordAmpSlope 0.000382713
tremorCoordAmpCoV 0.261263
tremorAccAmpMean 0.165939
tremorAccAmpSlope -0.00563054
tremorAccAmpCoV 0.24593
tremorPcRelVar 0.789774
tremorPcX -0.609091
tremorPcY -0.7931

ZigZag Offset Segment 1

Duration 9.92 s, Accuracy Estimate 0.027 (lower is better)

ZigZag Offset Segment 2

Duration 8.56 s, Accuracy Estimate 0.04 (lower is better)

ZigZag Offset Segment 3

Duration 8.36 s, Accuracy Estimate 0.033 (lower is better)

ZigZag Offset Segment 4

Duration 8.28 s, Accuracy Estimate 0.039 (lower is better)

ZigZag Offset Segment 5

Duration 7.56 s, Accuracy Estimate 0.053 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.61}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.6}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.3817627153049892}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Healthy’, ‘BM_HC_Sep22_score’: 0.2100335267206841}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.602357651694645}